Airplane: Prague Airport (which is about 15 kilometers west of the city) provides connections to most countries in Europe and outside Europe. Many airlines transport every day a lot of tourists from all around the world to the capital of Czech Republic. Among the cheapest companies traveling to Prague are, for example, Easy Jet, Wizz Air and Vueling but also others such as Czech Airlines, Finnair and Lufthansa have destination here. For more information visit http://www.prg.aero/cs/ flights
To get from the airport to the downtown easier, a convenient and fast option is to go by taxi. It has a rate of 516 CZK - 19 € or a little more.
Another comfortable option could be using the bus, namely the Airport Express or Student Agency that will take you downtown for 60CZK - 2.20 €. More information: http://www.cd.cz/vnitrostatni-cestovani/specialni-nabidky/airport-express-na-letiste-praha/-3679/
You will pay much less for transportation traveling by bus number 119, to travel to the nearest Metro - Dejvická. You will pay 24 CZK - 0.87 €. Then you have to grab the subway. http://jrportal.dpp.cz/jrportal/LineList.aspx?t=3&mi=5&n=0&lc=119
Train: By train you can travel easily to Prague through the Czech Republic. There are also direct connections to Prague from Slovakia, Hungary, Germany and Austria. For this you can travel from the train station in Prague - Hlavní Nádraží.
Bus: Other connections from Prague to Europe that there are available are, for example, the bus line Eurolines. In many cases it is the cheapest way to travel long distances but it is not advisable, since the trip takes time and also is tiring.
Car: The transport car can be useful especially when you have to scroll through more cities and go with lots of luggage. With no problem you can get to Prague and then travel throughout the Czech Republic by car as there are highways practically from all over Europe.